Peripheral Nerve Blocks
Targeted Pain Relief for Nerve-Related Pain Conditions
Pain originating from peripheral nerves can significantly affect movement, sleep, recovery, and quality of life. Whether caused by injury, surgery, nerve entrapment, or chronic pain conditions, irritated peripheral nerves can send persistent pain signals long after the initial problem occurs.
A peripheral nerve block is a minimally invasive, image-guided procedure that delivers local anesthetic and, in some cases, anti-inflammatory medication directly around a specific peripheral nerve. By temporarily interrupting pain signals, peripheral nerve blocks can help diagnose the source of pain, provide meaningful relief, and support recovery from injury or surgery.
Schedule a consultation today to determine whether a peripheral nerve block may be right for your condition.
What Is a Peripheral Nerve Block?
A peripheral nerve block is an injection performed around a specific nerve located outside the spinal cord and brain.
Unlike epidural injections or spinal procedures that target nerves near the spine, peripheral nerve blocks focus on nerves located in the:
- Arms
- Hands
- Shoulders
- Legs
- Feet
- Hips
- Knees
- Other localized areas of the body
The procedure temporarily interrupts pain transmission from the targeted nerve, helping reduce discomfort and identify whether that nerve is responsible for symptoms.
Depending on your condition, the injection may contain:
- Local anesthetic
- Corticosteroid medication
- Both anesthetic and anti-inflammatory medication
Conditions Treated with Peripheral Nerve Blocks
Peripheral nerve blocks may be used to diagnose or treat a variety of conditions, including:
- Peripheral neuropathy
- Post-surgical nerve pain
- Nerve entrapment syndromes
- Chronic regional pain syndrome (CRPS)
- Meralgia paresthetica
- Occipital neuralgia
- Intercostal neuralgia
- Ilioinguinal neuralgia
- Genicular nerve pain
- Shoulder nerve pain
- Chronic pain following injury
- Localized nerve inflammation
They may also be used as part of post-operative pain management plans to improve comfort and reduce opioid requirements.
Common Symptoms That May Respond to Peripheral Nerve Blocks
You may be a candidate if you experience:
- Burning pain
- Sharp or shooting pain
- Tingling sensations
- Numbness
- Electrical shock-like sensations
- Pain following surgery
- Localized nerve tenderness
- Persistent pain after an injury
- Pain that follows a specific nerve distribution
Because these symptoms often originate from a particular nerve, targeting that nerve directly can provide both diagnostic and therapeutic benefits.
How Peripheral Nerve Blocks Work
Peripheral nerves transmit sensory information, including pain signals, from different areas of the body to the brain.
When a nerve becomes irritated, compressed, inflamed, or damaged, it can generate persistent pain signals even after tissues have healed.
During a peripheral nerve block:
- Medication is delivered around the affected nerve
- Pain transmission is temporarily interrupted
- Inflammation may be reduced
- The physician evaluates how symptoms respond
Significant improvement following the injection often confirms that the targeted nerve is contributing to the pain.
Diagnostic and Therapeutic Benefits
One of the major advantages of peripheral nerve blocks is that they can serve both diagnostic and therapeutic purposes.
Diagnostic Benefit
Peripheral nerve blocks help:
- Identify the exact nerve causing pain
- Confirm suspected diagnoses
- Distinguish nerve pain from joint or muscle pain
- Guide future treatment planning
Therapeutic Benefits
The procedure may:
- Reduce pain intensity
- Improve mobility
- Support rehabilitation
- Improve sleep and daily function
- Provide temporary or longer-lasting symptom relief
Common Types of Peripheral Nerve Blocks
The type of block depends on the nerve involved and the location of symptoms.
Occipital Nerve Block
Used for:
- Occipital neuralgia
- Cervicogenic headaches
- Certain chronic headache conditions
Genicular Nerve Block
Used for:
- Chronic knee pain
- Osteoarthritis-related knee pain
- Post-knee replacement pain
Intercostal Nerve Block
Used for:
- Rib pain
- Chest wall pain
- Post-surgical thoracic pain
Ilioinguinal and Iliohypogastric Nerve Blocks
Used for:
- Groin pain
- Post-hernia surgery pain
- Pelvic nerve pain
Upper and Lower Extremity Nerve Blocks
Used for:
- Shoulder pain
- Arm pain
- Hand pain
- Leg pain
- Foot pain
Your physician will determine the most appropriate block based on your symptoms and diagnosis.
What to Expect During the Procedure
Peripheral nerve blocks are performed on an outpatient basis and often utilize ultrasound or fluoroscopic guidance for accuracy.

During Treatment
- The skin is cleaned and sterilized
- A local anesthetic may be applied
- Imaging guidance helps identify the targeted nerve
- Medication is injected around the nerve
Patients typically remain awake throughout the treatment.

Recovery and Aftercare
Recovery is usually quick with minimal downtime.
Most patients:
- Return home shortly after treatment
- Resume normal activities within 24 hours
- Experience temporary numbness in the treated area
- Notice reduced pain shortly after the procedure

How Long Does Pain Relief Last?
The duration of relief depends on:.
- The medication used
- The underlying condition
- The severity of nerve irritation
- Individual patient response
- Several hours
- Several days
- Several weeks
- Several months
Are You a Good Candidate?
You may benefit from a peripheral nerve block if:
- Pain appears localized to a specific nerve
- Conservative treatments have not provided adequate relief
- Surgery is not currently recommended
- Additional diagnostic information is needed
- You are experiencing chronic pain after surgery or injury
A comprehensive evaluation is required before treatment.
Safety and Potential Risks
Peripheral nerve blocks are generally considered safe when performed by experienced pain management specialists.
Potential risks include:
- Temporary soreness
- Bruising
- Bleeding
- Infection
- Allergic reaction
- Temporary numbness
- Temporary weakness
Serious complications are uncommon.
Contraindications and Patient Safety Screening
A thorough evaluation is performed before treatment.

Absolute Contraindications
- Active infection
- Allergy to injection medications
- Uncontrolled bleeding disorders
- Lack of patient consent

Relative Contraindications
- Blood-thinning medications
- Poorly controlled diabetes
- Pregnancy
- Certain neurological conditions
Clinical Evidence and Medical Support
Peripheral nerve blocks are widely used in pain medicine, anesthesiology, and rehabilitation settings.
Clinical guidance from organizations such as the American Society of Regional Anesthesia and Pain Medicine and American Society of Interventional Pain Physicians supports the use of peripheral nerve blocks for both diagnostic evaluation and pain management in appropriately selected patients.
When combined with imaging guidance and careful patient selection, peripheral nerve blocks can improve diagnostic accuracy and provide meaningful symptom relief.
Insurance Coverage and Medical Necessity
Many insurance plans cover peripheral nerve blocks when medically necessary.
Coverage may require:
- Documentation of chronic pain
- Clinical examination findings
- Prior conservative treatment attempts
- Supporting medical records
Depending on the condition being treated, pre-authorization may be required.
Our team can assist with insurance verification and approval processes.
Why Choose Our Clinic?
- Board-certified pain management specialists
- Advanced ultrasound and imaging-guided techniques
- Comprehensive diagnostic evaluations
- Personalized treatment plans
- Expertise in nerve-related pain conditions
- Focus on non-surgical pain relief and improved function
Our goal is to identify the source of pain and develop the most effective treatment strategy for long-term improvement.
Serving Patients in Lafayette & Opelousas
Our pain management specialists provide peripheral nerve blocks and advanced interventional pain treatments for patients throughout Acadiana.
Lafayette Office
- Lafayette, Louisiana
- (337) 362-8101
Opelousas Office
- Opelousas, Louisiana
- (337) 284-3200
We proudly serve patients from Lafayette, Opelousas, Scott, Broussard, Youngsville, Carencro, Breaux Bridge, New Iberia, Eunice, Crowley, Rayne, and surrounding communities.
Book Your Consultation
If chronic nerve pain, post-surgical pain, or localized pain is interfering with your daily activities, a peripheral nerve block may help identify the source of your symptoms while providing targeted relief.
Schedule your consultation today to learn whether a peripheral nerve block is right for you.
Lafayette Office
Opelousas Office
Frequently Asked Questions
What is a peripheral nerve block?
A peripheral nerve block is an injection that delivers medication around a specific nerve to temporarily interrupt pain signals and reduce symptoms.
Is a peripheral nerve block used for diagnosis or treatment?
It can be used for both. The procedure helps identify whether a specific nerve is causing pain while also providing symptom relief.
How long does a peripheral nerve block last?
Relief can last from several hours to several months depending on the medication used and the condition being treated.
Are peripheral nerve blocks painful?
Most patients experience only mild discomfort because the treatment area is numbed before the injection.
Can peripheral nerve blocks help after surgery?
Yes. Peripheral nerve blocks are commonly used to manage post-surgical pain and may help reduce the need for opioid medications during recovery.